产品货号：
Z18920
中文名称：
IkB Alpha/NFKBIA抗体
英文名称：
Anti-IkB Alpha/NFKBIA Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IkB Alpha/NFKBIA Antibody |
| 指标别名 | I kappa B alpha;IkappaBalpha;IkB alpha;IKBA;Ikβ-α;MAD 3;MAD3;NF kappa B inhibitor alpha;NFKBI;NFKBIA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | NFKBIA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human IKB alpha recombinant protein (Position:Q3-Q112).Human IKB alpha shares 87% and 86% amino acid (aa) sequence identity with mouse and rat IKB alpha,respectively. |
| 实际分子量 | 39KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NFKBIA,also called IKBA or MAD-3,is one member of a family of cellular proteins that function to inhibit the NF-κB transcription factor.It is mapped to 14q13.2.NFKBIA inhibits NF-κB by masking the nuclear localization signals(NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm.It moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export.The effect of the nonpathogenic bacteria is specific to the SCF complex substrates CTNNB1 and NFKBIA.This may help to explain the beneficial effects of treatment of inflammatory bowel disease with nonpathogenic probiotic enteric organisms.In addition,NFKBIA blocks the ability of NF-κB transcription factors to bind to DNA,which is required for NF-κB's proper functioning. |
| Uniprot ID | P25963 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor,alpha |
| 蛋白名全称 | NF-kappa-B inhibitor alpha |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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